|Andriol: Profile, General Information, Stacking and Use
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Pharmaceutical Name: Testosterone (as Undecanoate)
Chemical structure: androsta-4-en-3-one,17b-ol
Molecular weight of base: 288.429
Molecular weight of ester: 186.2936 (undecanoic acid, 11 carbons)
Andriol is a newly developed steroid, relatively speaking. Andriol is an orally available testosterone. Orally administered steroids have an altered base compound, and a slightly different effect by nature. It evokes a notable problem of hepatoxicity. A demand for an orally administered steroid existed since many patients feared needles or at least strongly disliked them. Researchers sought to create a steroid that would not require a 17-alpha-methyl alteration.
The solution was to determine a new method for delivery in which the liver was bypassed. This would mean that no alteration was needed to protect the steroid from being deactivated within the liver. That method of delivery was through lymphatic absorption. THe only other orally available steroid is methyltestosterone. When ingested with or after meals, it is reabsorbed through the mucosal cells in the small intestine via the lymphatic system. Thanks to this effect, andriol avoids first pass metabolism in the liver. Since first pass metabolism results in less agent being absorbed in the bloodstream, more andriol is absorbed in that manner. A certain portion of the drug is then converted into DHT, which has a very high affinity for androgen receptors. Thanks to this DHT conversion, andriol does not convert to estrogen at the same rate of many of its counterpart injectable testosterones, so chances of estrogen related side effects such as gyno and excess water retention are reduced when using it. As well, unlike its injectable counterparts, suppression of the HPTA is not quite as severe when using andriol.
The result of not having such large estrogen related side effects as fellow steroids is that the overall effectiveness of andriol is not as strong as its fellow steroids. It does have anabolic-androgenic characteristics, but not to the same degree as many other steroids. Injectables such as testosterone enanthate, testosterone cypionate, and sustanon are all more potent agents than andriol. Daily doses of over 200 mg daily would need to be consumed in order to make comparable gains off andriol than with its injectable counterparts. As a result of this excess of andriol, HPTA would be suppressed to a greater degree and the tendency for other side effects would become greater as well, in which case, a much less expensive route would just be to use an injectable steroid, either alone or in a stack.
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Acne, water retention, elevated blood pressure, aromatization (which can cause gyno), and suppression of the HPTA are all fairly low with normal use of andriol. Liver toxicity is a side effect, but also generally low in normal doses. At higher doses, all of these side effects can become more pronounced.
STACKING AND USE
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Andriol can be stacked with most other steroids. Since water retention issues are relatively rare with andriol, use of andriol while bulking or cutting are both possibilities. The use of ancillary drugs such as anti-estrogens like nolvadex or clomid are generally not considered to be very important since estrogen related side effects are extremely rare due to andriol's conversion to DHT. Estrogen related side effects normally stop when andriol doses are lowered or if its use is discontinued. This is unlike the injectable form of testosterone, in which case the cycle cannot simply be discontinued. 8-16 caps of andriol can be used each day and are best spread out throughout the day. Three equal doses throughout the day with meals would be a good recommendation.
CHEMICAL MUSCLE ENHANCEMENT
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